Barrier Repair

GXP™ Dermal Defense Cream

Intelligent Hydration. Everyday Resilience.

GXP™ Dermal Defense Cream combines Centella Asiatica plant-derived exosome technology with botanical, marine and skin-conditioning actives. Acmella Oleracea Extract addresses the appearance of expression lines. Micrococcus Lysate contributes to the resilience and visible stress-response story. Pomegranate Flower Extract with a Vitamin C derivative supports a smoother, firmer-looking appearance. Marine Exopolysaccharides add surface smoothing; a Marine Mineral Complex supports the environmental-stress narrative; and Low-Molecular-Weight Hyaluronic Acid replenishes hydration.

$195.00
1

50 ml
Expected to ship between November 15 and December 5, 2026, and no later than December 15, 2026.
Free shipping on every First Release pre-order.
Payment is charged in full when you pre-order.

How to use

Apply morning and evening after serum; massage until absorbed.

Purposeful ingredients
  • CENTELLA ASIATICA PLANT-DERIVED EXOSOMES
  • ACMELLA OLERACEA EXTRACT
  • MICROCOCCUS LYSATE
  • POMEGRANATE FLOWER EXTRACT + VITAMIN C DERIVATIVE
  • MARINE EXOPOLYSACCHARIDES
  • MARINE MINERAL COMPLEX
  • LOW-MOLECULAR-WEIGHT HYALURONIC ACID
Preorder information

Read our preorder terms for shipping, payment, and returns information.

The SkinFitness benefits

THE SCIENCE OF SKIN THAT LOOKS NOURISHED, STRONG, AND BEAUTIFULLY RESTORED.

Provides hydration and comfort; promotes a supple, smooth-looking complexion; supports resilience against visible environmental stress.

The GawleyMD™ difference

One signature technology. Purposefully selected complementary actives.

The science within

7 purposeful actives.

Hydration · Smoothness · Resilience — complementary ingredient functions within one formulation.

01 /

CENTELLA ASIATICA PLANT-DERIVED EXOSOMES

GXP™ plant-derived extracellular vesicle technology, researched for biological markers related to skin appearance.

02 /

ACMELLA OLERACEA EXTRACT

Botanical cosmetic smoothing active for expression lines.

03 /

MICROCOCCUS LYSATE

Biotechnology-derived ingredient selected for the appearance of skin challenged by environmental stress.

04 /

POMEGRANATE FLOWER EXTRACT + VITAMIN C DERIVATIVE

Botanical and antioxidant-focused combination for smoother, firmer-looking skin.

05 /

MARINE EXOPOLYSACCHARIDES

Marine-derived surface film for temporary smoothing and tightening.

06 /

MARINE MINERAL COMPLEX

Selected for environmental-stress positioning; does not provide proven SPF protection.

07 /

LOW-MOLECULAR-WEIGHT HYALURONIC ACID

Moisture-binding ingredient supporting softness and suppleness.

The ritual

Intelligent Hydration. Everyday Resilience.

Apply morning and evening after serum; massage until absorbed.

Build your daily ritual
GXP™ Dermal Defense Cream and packaging
Science and formula